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THROMBIN-JMI® (thrombin, topical, bovine origin) Clinical Pharmacology

12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action

THROMBIN-JMI requires no intermediate physiological agent for its action. It activates platelets and catalyzes the conversion of fibrinogen to fibrin, which are essential steps for clot formation. Failure to clot blood occurs in the case where the primary clotting defect is the absence of fibrinogen itself. The speed with which thrombin clots blood is dependent upon the concentration of both thrombin and fibrinogen.

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